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environmental influences of autism

Environmental: Welcome

REviews  on the environmental influences of autism

Environmental toxicants and autism spectrum disorders: a systematic review.

Rossignol, D.A., Genuis, S.J., Frye, R.E. Transl Psychiatry. 2014; 4:e360.

The putative role of environmental aluminium in the development of chronic neuropathology in adults and children. How strong is the evidence and what could be the mechanisms involved?

Morris, G., Puri, B.K., Frye, R.E. Metab Brain Dis. 2017; 32(5):1335-1355.

The Putative Role of Environmental Mercury in the Pathogenesis and Pathophysiology of Autism Spectrum Disorders and Subtypes.

Morris, G., Puri, B.K., Frye, R.E., Maes, M. Mol Neurobiol. 2017

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Case studies on environmental toxicants in autism

Environmental Toxicants and Autism Spectrum Disorder

Rossignol, D.A., Frye, R.E. Psychiatric Times. 2016; 33(9)

Mitochondrial dysfunction in the gastrointestinal mucosa of children with autism: A blinded case-control study.

Rose, S., Bennuri, S.C., Murray, K.F., Buie, T., Winter, H., Frye, R.E. PLoS One. 2017; 12(10):e0186377.

Unique acyl-carnitine profiles are potential biomarkers for acquired mitochondrial disease in autism spectrum disorder.

Frye, R.E., Melnyk, S., Macfabe, D.F.. Transl Psychiatry. 2013; 3:e220

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Toxicant Influences on
Mitochondrial Function in Autism

Oxidative Stress Challenge Uncovers Trichloroacetaldehyde Hydrate-Induced Mitoplasticity in Autistic and Control Lymphoblastoid Cell Lines.

Frye, R.E., Rose, S., Wynne, R., Bennuri, S.C., Blossom, S., Gilbert, K.M., Heilbrun, L., Palmer, R.F. Sci Rep. 2017; 7(1):4478.

Increased susceptibility to ethylmercury-induced mitochondrial dysfunction in a subset of autism lymphoblastoid cell lines

Rose, S., Wynne, R., Frye, R.E., Melnyk, S., James, S.J. J Toxicol. 2015;2015:573701.

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physiological effect of enteric short chain fatty acids in autism spectrum disorder

Gastrointestinal dysfunction in autism spectrum disorder: the role of the mitochondria and the enteric microbiome.

Frye, R.E., Rose, S., Slattery, J., MacFabe, D.F. Microb Ecol Health Dis. 2015; 26:27458.

Butyrate enhances mitochondrial function during oxidative stress in cell lines from boys with autism.

Rose, S., Bennuri, S.C., Davis, J.E., Wynne, R., Slattery, J.C., Tippett, M., Delhey, L., Melnyk, S., Kahler, S.G., MacFabe, D.F., Frye, R.E. Transl Psychiatry. 2018; 8(1):42.

Modulation of Immunological Pathways in Autistic and Neurotypical Lymphoblastoid Cell Lines by the Enteric Microbiome Metabolite Propionic Acid.

Frye, R.E., Nankova, B., Bhattacharyya, S., Rose, S., Bennuri, S.C., MacFabe, D.F. Front Immunol. 2017; 8:1670.

Modulation of mitochondrial function by the microbiome metabolite propionic acid in autism and control cell lines.

Frye, R.E., Rose, S., Chacko, J., Wynne, R., Bennuri, S.C., Slattery, J.C., Tippett, M., Delhey, L., Melnyk, S., Kahler, S.G., MacFabe, D.F. Transl Psychiatry. 2016; 6(10):e927.

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