The Microbiome and Autism
Increasing evidence suggests that the enteric microbiome plays a critical role in the etiology and symptomatology of ASD, at least in some cases. To better understand this connection, in June 2014 my staff and I organized and hosted the 1st International Symposium on the Microbiome in Health and Disease with a Special Focus on Autism followed by a workshop the next day focusing on approaches to studying and manipulating the enteric microbiome to improve autism symptoms. From this meeting a special issue of Microbial Ecology in Health and Disease was published. We have also investigated the clinical and basic research aspects of enteric microbiome metabolites on mitochondrial function
The microbiome as a treatment target in autism
Approaches to studying and manipulating the enteric microbiome to improve autism symptoms.
Frye, R.E., Slattery, J., MacFabe, D.F., Allen-Vercoe, E., Parker, W., Rodakis, J., Adams, J.B., Krajmalnik-Brown, R., Bolte, E., Kahler, S., Jennings, J., James, J., Cerniglia, C.E., Midtvedt, T. Microb Ecol Health Dis. 2015; 26:26878.
Enteric Ecosystem Disruption in Autism Spectrum Disorder: Can the Microbiota and Macrobiota be Restored?
Slattery, J., MacFabe, D.F., Kahler, S.G., Frye, R.E. Curr Pharm Des. 2016; 22(40):6107-6121.
The Significance of the Enteric Microbiome on the Development of Childhood Disease: A Review of Prebiotic and Probiotic Therapies in Disorders of Childhood.
Slattery, J., MacFabe, D.F., Frye, R.E. Clin Med Insights Pediatr. 2016; 10:91-107.